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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K7
All Species:
10.91
Human Site:
S378
Identified Species:
21.82
UniProt:
O43318
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43318
NP_003179.1
606
67196
S378
S
R
G
S
S
V
E
S
L
P
P
T
S
E
G
Chimpanzee
Pan troglodytes
XP_001160138
472
51727
P256
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
Rhesus Macaque
Macaca mulatta
XP_001099744
609
67549
S378
S
R
G
S
S
V
E
S
L
P
P
T
S
E
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q62073
579
64209
K351
T
I
K
R
L
E
S
K
L
L
K
N
Q
A
K
Rat
Rattus norvegicus
P0C8E4
606
67182
S378
S
R
G
S
S
V
E
S
L
P
P
T
S
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507638
595
66386
E367
A
S
R
G
S
S
V
E
S
L
P
P
S
E
S
Chicken
Gallus gallus
XP_001233491
604
67342
S368
G
R
L
S
L
P
P
S
R
G
S
S
V
E
S
Frog
Xenopus laevis
Q7T2V3
1005
111856
S519
K
C
K
G
Q
G
T
S
S
Y
S
P
P
G
S
Zebra Danio
Brachydanio rerio
NP_001018586
544
61104
I327
S
P
G
S
N
D
T
I
K
F
P
Y
K
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3Q6
678
75656
Q361
I
T
P
T
N
S
G
Q
L
D
N
N
P
L
F
Honey Bee
Apis mellifera
XP_397248
510
58111
K294
S
R
N
I
E
S
E
K
V
N
E
N
H
V
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795629
463
51420
M247
P
K
P
L
D
K
L
M
T
S
D
S
S
P
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.4
99.5
N.A.
N.A.
95
99
N.A.
91.4
91.7
21.9
70.6
N.A.
34.5
41.4
N.A.
39.9
Protein Similarity:
100
75.7
99.5
N.A.
N.A.
95
99.3
N.A.
93.7
93.7
35.7
77.8
N.A.
52.2
58.7
N.A.
51.4
P-Site Identity:
100
13.3
100
N.A.
N.A.
6.6
100
N.A.
26.6
26.6
6.6
26.6
N.A.
6.6
20
N.A.
6.6
P-Site Similarity:
100
13.3
100
N.A.
N.A.
13.3
100
N.A.
33.3
33.3
6.6
33.3
N.A.
20
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
9
0
0
0
9
9
0
0
0
0
% D
% Glu:
0
0
0
0
9
9
34
9
0
0
9
9
0
42
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% F
% Gly:
9
0
34
17
0
9
9
0
0
9
0
0
0
9
25
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
9
9
0
17
0
0
0
9
0
0
9
0
0
0
0
% I
% Lys:
9
9
17
0
9
9
0
17
17
0
9
0
9
0
17
% K
% Leu:
0
0
17
9
17
0
17
0
42
17
0
0
0
17
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% M
% Asn:
0
0
9
0
17
9
0
0
0
9
9
25
0
0
0
% N
% Pro:
17
17
17
0
0
9
9
9
0
34
42
17
17
17
0
% P
% Gln:
0
0
0
0
9
0
0
9
0
0
0
0
9
0
0
% Q
% Arg:
0
42
9
9
0
0
0
0
9
0
0
0
0
0
0
% R
% Ser:
42
9
0
42
34
25
9
42
17
9
17
17
50
0
34
% S
% Thr:
9
9
0
9
0
0
17
0
9
0
0
25
0
0
0
% T
% Val:
0
0
0
0
0
25
9
0
9
0
0
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _